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. 2020 Mar 9;11(2):229–240. doi: 10.14336/AD.2019.0510

Figure 2.

Figure 2.

The ketogenic diet improved cardiac function and alleviated cardiac remodeling in db/db mice. A) Feeding the KD improved the cardiac function in db/db mice. Typical echocardiogram images are shown in the left panel. LV ejection fraction, LV internal dimension diastole (LVIDd), and LV internal dimension systole (LVIDs) are shown in the right and lower panels; n=6 mice from each group. B) Cardiac phenotypes in the mice after 2 months of feeding the KD. Four-chamber view cardiac sections stained with hematoxylin and eosin staining. Scale bar, 1 mm. Heart weight and heart weight-to-tibia length ratio are shown in the right panel; n=10 mice from each group. C) Cardiac fibrosis in mice after 2 months of feeding the KD. Sirius red staining. Scale bar, 200μm. Cardiac fibrosis quantification as a percentage of the red stained area vs. total area stained by Sirius red is shown in the right panel; n=5 mice from each group. Values are the mean ± SEM. Data were analyzed using two-way ANOVA, followed by unpaired t-tests. *, P<0.05. **, P<0.01. ns indicates no significance.