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. 2020 Mar 9;11(2):229–240. doi: 10.14336/AD.2019.0510

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Copyright: © 2020 Guo et al.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 3. — The ketogenic diet prevented mitochondrial fission and improved mitochondrial function in the myocardium of db/db mice. A) Cardiac mitochondrial morphology in myocardial samples. Typical images obtained from electron microscopy are shown in the left panel. Scale bar, 1 μm. Average mitochondrial size and mitochondrial number are shown in the right panel; n=6 mice from each group. B) Mitochondrial respiratory control ration; n=5 mice from each group. C) ATP levels in the heart of the mice; n=5 mice from each group. D) The content of mitochondrial dynamics-related proteins in myocardial samples. Statistical results are shown in the right panel; n=6 mice from each group. Values are the mean ± SEM. Data are analyzed using two-way ANOVA, followed by unpaired t-tests. *, P<0.05. **, P<0.01. ns indicates no significance.