Figure 4.

The ketogenic diet suppressed oxidative stress in the heart of db/db mice. A) Representative fluorescence microscopic image of DHE staining (red fluorescence) and DAPI-staining (blue fluorescence). Results derived from 5 different mice are shown below. Scale bar, 100 μm. Feeding the KD increased the activity of MnSOD (B) and decreased the content of MAD (C) in the myocardium of db/db mice; n=6 mice from each group. Values are the mean ± SEM. Data were analyzed using two-way ANOVA, followed by unpaired t-tests. *, P<0.05. **, P<0.01 versus Control.