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. 2020 Mar 9;11(2):229–240. doi: 10.14336/AD.2019.0510

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Copyright: © 2020 Guo et al.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 6. — BHB attenuated high glucose induced apoptosis in cardiomyocytes through the PI3K/Akt pathway. A) The KD increased the cardiac contents of PI3K and the ration of p-Akt/Akt in the myocardium of db/db mice. The typical images of western blot images are shown in the left panel. The statistical results are shown in the right panel; n=6 mice from each group. B) Effects of BHB on increasing the ration of Bcl2/Bax and p-Akt/Akt were blunted by the PI3K/Akt inhibitor wortmannin in cardiomyocytes exposed to high glucose; n=6. C) BHB decreased caspase-3 activity in cardiomyocytes exposed to high glucose; n=6. D) BHB protected cardiomyocytes against high glucose-induced apoptosis; n=6. Values are the mean ± SEM. Data were analyzed using two-way ANOVA, followed by unpaired t-tests. *, P<0.05. **, P<0.01.