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. 2020 Mar 9;11(2):241–253. doi: 10.14336/AD.2019.0618

Figure 5.

Figure 5.

Summary of the effects on iTh17 cells of PRI-2191 (tacalcitol) treatment of young and aged OVX mice bearing 4T1 mammary gland cancer. (A) PRI-2191, by increasing osteopontin level, may indirectly potentiate the differentiation of Th17 cells and the secretion of IL-17 by them. The direct effect of PRI-2191 after binding with VDR on the expression of osteopontin and genes responsible for Th17 differentiation is also considered. (B) In old OVX mice, the observed reduction in the secretion of osteopontin may contribute to reduced secretion of IL-17. Continuous red lines show the effects of PRI-2191 observed in the orthotopic 4T1 mouse breast cancer model, where PRI-2191 stimulated metastasis in young mice and inhibited in old OVX mice. Dotted lines indicate the effects of osteopontin on Th17 cells differentiation (through CD44 or other receptors) observed by other authors in other models (non-cancerous).