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. 2020 Mar 6;11:228. doi: 10.3389/fimmu.2020.00228

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Copyright © 2020 Erdei, Tóth, Nagy, Nyakundi, Fejes, Nagy, Novák, Bognár, Balogh, Paragh, Kappelmayer, Bácsi and Jeney.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Time-dependent accumulation of Hb, metHb, and ferrylHb in post-IVH CSF samples. CSF samples (n = 20) were obtained from preterm infants diagnosed with grade III IVH at different time intervals after the onset of IVH. (A) Physical appearance of CSF samples obtained at different time intervals after the onset of IVH (days 0–20, 21–40, 41–60). (B–D) Concentrations of Hb, metHb, and ferrylHb were quantified spectrophotometrically in CSF samples. Closed circles represent individual samples, red circles represent patients that died before 6 months of age, and bars represent mean ± SD values. P-values were calculated using one-way ANOVA followed by Tukey’s multiple comparison analysis. *p < 0.05.