Table 1.
Vancomycin MICs and substitutions in VanSRCd for laboratory mutants and clinal isolates
| Strain or number of isolates with a mutation | MIC (mg/L) | Substitution in VanSR |
|
|---|---|---|---|
| VanSCd | VanRCd | ||
| Laboratory mutants | |||
| WT R20291 | 1 | – | – |
| WS2 | 8 | Arg314Leu | – |
| WS4 | 16 | Gly319Asp | – |
| Clinical isolates | |||
| 1a | 8 | Ser313Phe | – |
| 1b | 8 | Thr349Ile | – |
| 9c,d | 4–8e | – | Thr115Ala |
Eleven clinical isolates were analysed. They were from: the Texas Medical Center (aMT1470, bMT5006, cMT3678, cMT5055, cMT1349, cMT443, cMT201, cMT4887 and cMT3914); and Israel (d491858 and d490054).
e
Isolates from Israel had MICs of 8 mg/L, while those from the Texas Medical Center had MICs of 4 mg/L.