Table 2.

Pharmacokinetic parameter estimates for the structural and final models

Parameter	Structural model (RSE %) [95% CI]	Final model (RSE %) [95% CI]
CL (L/h)	8.42 (9.3) [7.0–10.0]	–
CL70kg${\times \left(\frac{\mathrm{TBW}}{70}\right)}^{\mathrm{\theta }1}$
CL70kg (L/h)	–	5.83 (4.4) [5.33–6.27]
θ1	–	0.54 (26) [0.26–0.78]
Q (L/h)	51.9 (27) [30.0–83.0]	60.3 (19) [41.2–85.8]
V c (L)	222 (11) [182–267]	–
V c; 70kg ${\times \left(\frac{\mathrm{TBW}}{70}\right)}^{\mathrm{\theta }2}$
Vc; 70kg (L)	–	150 (12) [119–187]
θ2	–	0.77 (24) [0.40–1.12]
V p (L)	132 (9.3) [109–153]	–
V p; 70kg ${\times \left(\frac{\mathrm{TBW}}{70}\right)}^{\mathrm{\theta }3}$
Vp; 70kg (L)	–	96.2 (12) [73.7–118]
θ3	–	1.16 (18) [0.779–1.56]
Inter-individual variability (%)a
CLb	37.1 (19) [25.0–55.2]	–
Vcb	44.4 (17) [33.0–66.2]	29.5 (16) [22.2–42.6]
Residual error (%)
σpropb	17.6 (5.4) [16.0–19.6]	16.4 (5.1) [15.1–18.2]
OFV	−506.2	−589.8

Q, inter-compartmental CL between V_c and V_p; σ_prop, proportional residual error; RSE, relative standard error based on covariance step in NONMEM; 95% CI, 95% CI obtained from the SIR procedure.

^aCalculated as $\sqrt{\left(e^{{\omega }^2}-1\right)}$.

^bη and ε shrinkage of inter-individual variability and residual error are <10%.