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| Compound number | R1 | IC50 (μM) |
|
| MtbLeuRS | MtbMetRS | ||
| 2 | C6H4-4-NO2 | 5.8 ± 4.1 (3) | 4.2 ± 1.3 (3) |
| 3 | C6H4-4-F | 12.5 ± 4.7 (3) | 10.7 ± 8.4 (4) |
| 3a | CH3 | 95 ± 10 (2) | ND |
| 4 | C6H3-2,4-dCl | 27.3 ± 1.3 (2) | 22.7 ± 7.2 (3) |
| 5 | C6H4-3-NO2 | 8.9 ± 1.7 (2) | 6.5 ± 0.4 (2) |
| 5a | C6H5 | 24.1 ± 5.5 (3) | 37.5 ± 5.3 (3) |
| 5b | CH3 | 38.4 ± 9.2 (3) | 123 ± 15 |
