Fig. 2. Flexibility of the Fab domain in hexameric IgM multimers. Root mean square fluctuation (RMSF) values were mapped onto the protein surface (left) and protein number density (right) from a 10 μs simulation for the (A) Pertuzumab IgM hexamer and (B) Trastuzumab IgM hexamer. The dotted red line shows the approximate boundary between Fc and Fab domains.
