Table 2.
Top 10 adverse effects (all grade) associated with 2/1 vs. 4/2.
| Adverse effects | No. of studies | 2/1 group (event/total) | 4/2 group (event/total) | RR (95% CI) | P-value | Heterogeneity | |
|---|---|---|---|---|---|---|---|
| I2 (%) | P-value | ||||||
| Leukopenia | 4 | 86/135 | 111/135 | 0.86 [0.73, 1.00] | 0.05 | 14 | 0.32 |
| Thrombocytopenia/Platelet disorder | 7 | 124/234 | 224/438 | 0.86 [0.70, 1.06] | 0.15 | 64 | 0.01 |
| Hand-foot syndrome | 7 | 111/234 | 274/438 | 0.70 [0.60, 0.82] | <0.0001 | 15 | 0.32 |
| Neutropenia | 5 | 59/146 | 106/168 | 0.62 [0.49, 0.79] | <0.0001 | 30 | 0.22 |
| Anemia | 6 | 92/193 | 129/230 | 0.80 [0.67, 0.95] | 0.01 | 40 | 0.14 |
| Hypothyroidism | 6 | 89/208 | 188/408 | 0.83 [0.69, 1.01] | 0.06 | 5 | 0.39 |
| Stomatitis/Mucositis | 5 | 67/161 | 205/346 | 0.67 [0.54, 0.83] | 0.0003 | 0 | 0.44 |
| Hypertension | 7 | 88/234 | 227/441 | 0.65 [0.53, 0.79] | <0.0001 | 32 | 0.18 |
| Fatigue | 7 | 117/234 | 327/438 | 0.67 [0.59, 0.77] | <0.00001 | 42 | 0.11 |
| Abdominal pain/Diarrhea | 7 | 85/234 | 218/438 | 0.67 [0.48, 0.92] | 0.02 | 61 | 0.02 |
4/2, 4-weeks-on and 2-weeks-off; 2/1, 2-weeks-on and 1-week-off; RR, risk ratio; CI, confidence interval.