Table 3.
Top 10 adverse effects (grade 3–4) associated with 2/1 vs. 4/2.
| Adverse effects | No. of studies | 2/1 group (event/total) | 4/2 group (event/total) | RR (95% CI) | P-value | Heterogeneity | |
|---|---|---|---|---|---|---|---|
| I2 (%) | P-value | ||||||
| Leukopenia | 4 | 12/135 | 18/150 | 0.76 [0.37, 1.57] | 0.46 | 34 | 0.21 |
| Thrombocytopenia/Platelet disorder | 8 | 13/255 | 41/448 | 0.53 [0.29, 0.98] | 0.04 | 0 | 0.72 |
| Hand-foot syndrome | 8 | 21/255 | 56/451 | 0.61 [0.38, 0.98] | 0.04 | 16 | 0.31 |
| Neutropenia | 7 | 19/191 | 33/208 | 0.62 [0.37, 1.04] | 0.07 | 0 | 0.46 |
| Anemia | 6 | 15/190 | 16/210 | 1.02 [0.52, 1.98] | 0.96 | 0 | 0.67 |
| Hypothyroidism | 6 | 2/208 | 9/411 | 0.58 [0.17, 1.95] | 0.38 | 0 | 0.67 |
| Stomatitis/Mucositis | 5 | 4/161 | 23/349 | 0.38 [0.13, 1.11] | 0.08 | 0 | 0.74 |
| Hypertension | 8 | 15/255 | 53/451 | 0.45 [0.26, 0.77] | 0.004 | 0 | 0.71 |
| Fatigue | 8 | 14/255 | 57/451 | 0.42 [0.24, 0.73] | 0.002 | 0 | 0.88 |
| Abdominal pain/Diarrhea | 6 | 8/208 | 24/408 | 0.75 [0.39, 1.43] | 0.38 | 49 | 0.08 |
4/2, 4-weeks-on and 2-weeks-off; 2/1, 2-weeks-on and 1-week-off; RR, risk ratio; CI, confidence interval.