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. 2020 Mar 9;13:2067–2092. doi: 10.2147/OTT.S233672

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© 2020 Tang and Hann.

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circRNAs involve in cancer progression by regulation of gene splicing, transcription, translation and cell autophagy. (A) circRNAs influence the progression of human cancers by regulating gene splicing, transcription and translation via interaction with U1 small nuclear RNA (snRNA), RNA polymerase II (Pol II), and alternative splicing regulator. Moreover, circRNA containing AUG sites and open reading frame (ORF) driven by the internal ribosome entry site (IRES) may translate into the functional protein. (B) circRNAs are associated with the tumor cell autophagy through regulating the autophagy-related signaling pathways.