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. 2020 Mar 9;15:1569–1583. doi: 10.2147/IJN.S220057

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© 2020 Ou et al.

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Schematic illustration shows the synthesis of GO-PEI-inhibitor complexes and miR-214 inhibitor delivery. GO was conjugated with PEI to form positively charged GO-PEI complexes. For miR-214 inhibitor delivery, negatively charged miR-214 inhibitor was loaded onto the GO-PEI complexes by electrostatic interactions. The miR-214 inhibitor was delivered into cells and inhibited the expression and function of miR-214, subsequently regulating the expression of downstream genes. GO-PEI-inhibitor was applied to mice tumors through intratumoral injection.