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. 2020 Mar 9;15:1569–1583. doi: 10.2147/IJN.S220057

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© 2020 Ou et al.

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GO-PEI-inhibitor displayed high anticancer efficiency in the OSCC xenograft mouse model by intratumoral injection. (A) Representative images of tumor tissue treated with PBS, the miR-214 inhibitor, GO-PEI or GO-PEI-inhibitor complexes (30 μL). (B) Relative changes in tumor volume at different time points. The values are presented, n=5. *P<0.05. (C) Relative changes in body weight over time and the values are presented, n=5. (D) Representative images of H&E staining of tumor tissues, the black arrow points to the blood vessel, the white arrow points to the accumulated GO-PEI and the red arrow points to the dead cells. Scale bars: 50 μm. (E) Immunohistochemical staining of p-PTEN, p-p53 and Ki67 in different treatment groups is shown. Scale bars: 50 μm.