Table 1. Effect of chronic codeine use on body weight, testicular weight and relative testicular weight.

Group	Initial BW (g)	Final BW (g)	Difference (g)	Difference (%)	PTW (g)	PTW/BWX 100
Control	872.00±69.63	1379.1±54.51	507.05±32.93	58.6257±7.57	2.84±0.19	0.21±0.01
Low-dose codeine	866.62±60.21	1353.8±71.95	487.18±26.15	56.3971±4.24	1.40±0.55*	0.11±0.04*
High-dose codeine	818.91±46.69	1305.2±64.86	486.32±26.69	59.4614±3.22	0.91±0.38*	0.07±0.03*

Values represent mean±SD for 7 replicates in each group. BW, body weight of rats; PTW, paired testicular weight.

*p < 0.05 vs control

#p < 0.05 vs low-dose codeine