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Modeled IGF-I SDS fluctuations over the week. Insulin-like growth factor-I (IGF-I) SDS profiles for somapacitan were derived by population PK/PD modeling from the REAL 3 trial. Daily GH IGF-I SDS profiles are shown for reference and were derived by population PK/PD modeling of phase 1 data (daily GH model not published). d, day; GH indicates growth hormone; PK/PD, pharmacokinetic/pharmacodynamic; SDS, SD score; wk, week.
