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. 2020 Jan 9;105(4):e1847–e1861. doi: 10.1210/clinem/dgz310

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© Endocrine Society 2020.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 8. — Mean IGF-I SDS: observed and derived values. Somapacitan trough values are an average from values obtained 7 days after dose at weeks 4, 13, and 39. Somapacitan peak values are an average from values obtained 1 to 4 days after dose at weeks 26 and 52. Somapacitan average values were derived by population PK/PD modeling. Daily GH IGF-I levels from week 26 and 52 are shown for reference. Points and bars are means with SD. d, day; GH indicates growth hormone; PK/PD, pharmacokinetic/pharmacodynamic; SDS, SD score; wk, week.