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. 2020 Mar 13;161(4):bqz007. doi: 10.1210/endocr/bqz007

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Published by Oxford University Press on behalf of the Endocrine Society 2020.

This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)

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Figure 8. — Estradiol treatment significantly stimulates bone mass in Igfbp2^–/– and Igfbp2^+/+ male mice and RPTPβ expression in null males. (A) Whole body areal bone mineral density (aBMD) changes during estrogen treatment between 8 and 16 weeks of age (n = 10/treatment/genotype). (B) Distal femur trabecular bone volume/total volume (BV/TV) in Igfbp2^+/+ and Igfbp2^–/– after 8 weeks of estradiol treatment. Femoral mRNA expression of PTN (C) and RPTPβ (D) (n = 6/ treatment /genotype). For all analysis *P < .05; **P < .01; ***P < .001; ****P < .0001.