Appendix 1—table 3. Average number of solvent molecules in the region from −0.9 to 0.9 nm from membrane center in the last 10 µs.
| Peptide | Variant | Membrane | Mean | Standard deviation |
|---|---|---|---|---|
| – | – | POPC | 0.7 | 1.1 |
| LL-37 | WT | POPC | 27.4 | 11.9 |
| WT* | POPC | 9.8 | 6.1 | |
| G14L | POPC | 15.3 | 7.8 | |
| I13G/G14I | POPC | 24.6 | 8.6 | |
| Buforin II | WT | POPC | 10.5 | 7.6 |
| WT* | POPC | 27.6 | 10.3 | |
| P11L | POPC | 43.7 | 17.8 | |
| P11A | POPC | 23.1 | 8.6 | |
| P11G | POPC | 7.7 | 6.0 | |
| P11G* | POPC | 21.4 | 7.4 | |
| P11G^ | POPC | 20.0 | 14.8 | |
| WT | POPC:POPG (1:1) | 4.0 | 3.2 | |
| WT* | POPC:POPG (1:1) | 6.0 | 3.6 | |
| P11L | POPC:POPG (1:1) | 14.9 | 8.0 | |
| P11A | POPC:POPG (1:1) | 5.3 | 3.6 | |
| P11G | POPC:POPG (1:1) | 3.7 | 3.2 | |
| WT | POPC:POPS (1:1) | 3.8 | 3.0 | |
| WT* | POPC:POPS (1:1) | 7.8 | 4.0 | |
| P11L | POPC:POPS (1:1) | 5.4 | 3.6 | |
| P11A | POPC:POPS (1:1) | 7.7 | 4.9 | |
| P11G | POPC:POPS (1:1) | 3.9 | 3.3 | |
| Magainin 2 | WT | POPC | 16.1 | 6.8 |
| WT* | POPC | 30.1 | 8.9 | |
| G13P | POPC | 60.3 | 18.8 | |
| G13P* | POPC | 45.3 | 11.5 | |
| δ-lysin | WT | POPC | 15.8 | 6.8 |
| WT* | POPC | 12.4 | 5.7 | |
| CandK | WT | POPC | 6.9 | 3.4 |
| WT* | POPC | 6.0 | 4.3 | |
| CandKR | WT | POPC | 7.1 | 4.2 |
| P14Q/Q15P | POPC | 6.6 | 4.5 |
* a sequence where glycine/proline (usually kink-forming residues) was forced into an α-helix.
^ a sequence where only single residue formed the flexible kink.
Lipid ratio is expressed as mol/mol.