Fig. 2. Hsp90 promotes the formation of small oligomeric species of Tau.

Dot blot summarizing the results of density gradient centrifugation and quantification (the color code represents Tau preparations as reported on top of the right graph): Pure Tau is mostly monomeric. Heparin induces formation of high–molecular weight fibrils. Hsp90 leads to an increase in small Tau oligomeric species, while formation of fibrils is prohibited. A.U., arbitrary units.