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. 2020 Mar 13;6(11):eaax6999. doi: 10.1126/sciadv.aax6999

Fig. 3. Oligomerization is mediated by the AD fibril core region of Tau.

Fig. 3

Information about intermolecular Tau/Tau interactions obtained with DEER of singly spin-labeled Tau in the absence (dark gray) and presence (light gray) of Hsp90. Nonzero Δeff values represent small amounts of nonmonomeric Tau in the absence of Hsp90. Hsp90 increased Δeff values for Tau-322* and Tau-354* (light green bars) in accordance with an increase in Tau oligomers mediated by R3/R4 of Tau-RD. Positions probed in the experiment are also indicated on a schematic representation of the Tau sequence, with indicated Hsp90-binding site (25) and the core of the AD fibril (11), yellow and green stars indicating spin labeling positions without and with changes in Δeff upon addition of Hsp90, respectively.