Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Mar 13;6(11):eaax6999. doi: 10.1126/sciadv.aax6999

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license, which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.

PMC Copyright notice

Fig. 4 — (A) Local side-chain dynamics accessed by cw EPR of 28 μM singly spin-labeled Tau derivatives: Rotational correlation times τ_corr determined in the absence (dark gray) and presence (light gray) of 56 μM Hsp90 and respective changes Δτ_corr (purple/pink) are shown. Arrows indicate a decrease (pink) or increase (purple) in side-chain mobility at the respective site. (B) Intramolecular distance information obtained by DEER spectroscopy with doubly spin-labeled Tau derivatives: Effective modulation depths Δ_eff determined in the absence (dark gray) and presence (light gray) of Hsp90 and respective changes ΔΔ_eff (light/dark green) are shown. Arrows indicate a decrease (light green) or increase (dark green) in spin label separation.