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. Author manuscript; available in PMC: 2020 Sep 18.
Published in final edited form as: J Am Chem Soc. 2019 Sep 5;141(37):14593–14602. doi: 10.1021/jacs.9b03689

Figure 5: RNA base sequence tunes material states of FUSR/G-rich LCD condensates.

Figure 5:

a) Trap-induced fusion time lapse images of poly(U)-FUSR/G-rich LCD droplets and poly(A)-FUSR/G-rich LCD droplets. b) Normalized Fluorescence recovery after photobleaching (FRAP) intensity time-trace for FUSR/G-rich LCD-RNA condensates. c) Trap-induced fusion time lapse images of droplets formed by poly(U) and poly(A) RNA with FUSRGG3, respectively. d) Relaxation times of the FUS-RNA condensates are approximately one order of magnitude higher for poly(A) RNA as compared to poly(U) RNA. Scale bars in a and c represent 5 μm. Corresponding movies for a and c are provided as Supplementary Movies 5 and 6.