Table 3:
Multivariable analysis of predictors of post-ablation local and overall recurrence
| Entire Study Cohort (N=330) | HPV Testing Eligible Cohort (N=291) | Longitudinal HPV16/18 Cohort (N=184) | ||||
|---|---|---|---|---|---|---|
| HR for Local Recurrence (95% CI) | HR for Overall Recurrence (95% CI) | HR for Local Recurrence (95% CI) | HR for Overall Recurrence (95% CI) | HR for Local Recurrence (95% CI) | HR for Overall Recurrence (95% CI) | |
| Age | 1.0 (0.9–1.0) | 1.0 (0.9–1.0) | 1.0 (0.9–1.0) | 1.0 (0.9–1.0) | 1.0 (0.9–1.0) | 1.0 (0.9–1.0) |
| Female | 0.9 (0.4–2.0) | 1.3 (0.8–2.1) | 0.9 (0.4–1.9) | 1.2 (0.7–2.2) | 0.8 (0.3–2.1) | 0.8 (0.3–2.1) |
| Race/Ethnicity | ||||||
| White | Reference | Reference | Reference | Reference | Reference | Reference |
| Black | 0.7 (0.5–1.2) | 0.6 (0.4–1.0) | 0.9 (0.5–1.5) | 0.7 (0.4–1.1) | 1.1 (0.5–2.2) | 0.7 (0.4–1.2) |
| Hispanic | 0.8 (0.5–1.2) | 0.7 (0.5–1.0) | 0.9 (0.6–1.5) | 0.8 (0.5–1.2) | 1.2 (0.7–2.2) | 0.7 (0.4–1.2) |
| Other | 1.1 (0.6–2.0) | 0.8 (0.5–1.4) | 1.0 (0.5–2.0) | 0.8 (0.4–1.2) | 1.7 (0.6–4.7) | 0.8 (0.3–2.0) |
| Smoking Status | ||||||
| Never Smoker | Reference | Reference | Reference | Reference | Reference | Reference |
| Former Smoker | 1.1 (0.7–1.7) | 1.0 (0.7–1.4) | 1.0 (0.7–1.7) | 0.9 (0.6–1.4) | 1.1 (0.6–2.0) | 1.2 (0.7–1.9) |
| Current Smoker | 1.7 (1.1–2.4) | 1.8 (1.3–2.5) | 1.3 (0.9–2.1) | 1.7 (1.2–2.5) | 1.2 (0.7–2.2) | 1.8 (1.1–2.9) |
| HIV Viremia | ||||||
| Non-viremic | Reference | Reference | Reference | Reference | Reference | Reference |
| Viremic | 1.5 (1.0–2.2) | 1.3 (0.9–1.8) | 1.3 (0.9–2.0) | 1.2 (0.8–1.7) | 1.9 (1.1–3.3) | 1.4 (0.8–2.3) |
| Lesion Burden at Baseline | ||||||
| Solitary | Reference | Reference | Reference | Reference | Reference | Reference |
| Multiple | 1.8 (1.3–2.5) | 1.4 (1.1–1.9) | 1.8 (1.2–2.6) | 1.3 (0.9–1.8) | 1.7 (1.1–2.8) | 1.3 (0.9–2.0) |
| High Risk HPV Types | ||||||
| No High Risk HPV | -- | -- | Reference | Reference | -- | -- |
| HPV16/18 | -- | -- | 4.7 (1.1–19.5) | 5.6 (1.7–17.9) | -- | -- |
| Other HR HPV | -- | -- | 3.4 (0.8–14.1) | 4.3 (1.3–13.7) | -- | -- |
| HPV 16/18 Longitudinal Positivity | ||||||
| Always HPV 16/18 Negative | Reference | Reference | ||||
| Intermittent HPV 16/18 Positivity | 1.9 (0.6–6.3) | 2.2 (0.8–6.3) | ||||
| Persistent HPV 16/18 Positivity | 2.3 (1.4–3.7) | 2.0 (1.3–3.1) | ||||
HR: Hazard ratio; HPV: Human papillomavirus
Persistent HPV 16/18 Positivity: HPV16/18 was detected in both baseline and follow-up cytology samples.
Intermittent HPV 16/18 Positivity: HPV16/18 was detected only once, either at baseline or follow-up.
Always HPV 16/18 Negative: HPV 16/18 was neither detected at baseline nor at follow-up.