Table 4.

Examining varied parings of R¹/R² substitutions on the aminopyrazole ring. Fold selectivity >5 for any compound is highlighted in red.

Entry	Compound	X	R1	R2	C. neoformans EC50a (μM)	C. neoformans fold- selectivityb	C. albicans EC50c (μM)	C. albicans fold- selectivityb
1	88	A		CH3	0.252	0.2	0.121	0.3
2	89	A		CH3	0.560	0.2	0.116	0.4
3	90	A		CH3	0.700	0.2	0.134	0.4
4	91	A	CH3	Ph	0.078	9.2	0.328	0.4
5	92	B			0.127	8.2	0.395	0.8
6	93	C			0.066	6.7	0.213	0.6
7	94	B	tBu	Ph	0.517	9.7	0.379	3.9
8	95	C			0.379	6.7	0.182	4.1
9	96	B		Ph	0.615	0.4	0.059	1.7
10	97	C			0.419	0.3	0.034	1.4
11	98	B	iBu	Ph	0.315	1.7	0.100	1.6
12	99	C			0.147	1.8	0.070	1.4

EC₅₀ and selectivity values were determined as described for Table 1.