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. Author manuscript; available in PMC: 2021 Mar 12.
Published in final edited form as: J Med Chem. 2019 Sep 26;63(5):2139–2180. doi: 10.1021/acs.jmedchem.9b00826

Table 6.

Aminopyrazoles with whole cell anti-cryptococcal activity

Entry Compound MIC (μM) FP EC50 (nM) FP Selectivity
1 21 6.25 877 2.5
2 27 12.5 787 2.2
3 29 6.25 705 2.7
4 49 12.5 1026 1.4
5 89 25 560 0.2

Minimum inhibitory concentration (MIC) value for compounds against C. neoformans (Strain H99) was determined in dose-response format, in technical duplicate. Experiments were conducted in RPMI medium at 37 °C for 48 h. Relative viable cell number was measured by standard dye reduction (resazurin) assay.