Table 4.
Generalized linear mixed regression analysis for OMWQ-HN patient reported outcomes, (mean +/−SD).
| Baseline | Mid-Treatment (Week 3) | End of Treatment (Week 7) | p-value | ||||
|---|---|---|---|---|---|---|---|
| Arm 1 (n=31) | Arm 2 (n=29) | Arm 1 (n=29) | Arm 2 (n=29) | Arm 1 (n=23) | Arm 2 (n=21) | ||
| OMWQ-HN | |||||||
| OHa | 71 +/−28 | 86 +/−14 | 78 +/−15 | 71 +/−20 | 55 +/−19 | 63 +/−19 | 0.05 |
| MTSa | 18 +/−26 | 13 +/−22 | 34 +/−27 | 42 +/−27 | 46 +/−24 | 48 +/−27 | 0.87 |
| MTSb | 0.4 +/−0.7 | 0.4 +/−0.8 | 2.4 +/−1.1 | 2.2 +/−1.0 | 2.0 +1.1 | 2.1 +/−1.1 | 0.51 |
| Limitations due to MTSC | |||||||
| Swallowing | 0.4 +/−1.0 | 0.6 +/−1.2 | 1.3 +/−1.2 | 1.6 +/−1.2 | 1.6 +/−1.2 | 1.4 +/−1.1 | 0.72 |
| Drinking | 0.3 +/−1.0 | 0.5 +/−1.2 | 0.9 +/−1.2 | 0.8 +/−1.1 | 1.7 +/−1.4 | 1.6 +/−1.1 | 0.60 |
| Eating | 0.5 +/−1.2 | 0.5 +/−1.1 | 1.0 +/−1.3 | 1.6 +/−1.3 | 2.2 +/−1.5 | 1.9 +/−1.3 | 0.97 |
| Talking | 0.4 +/−1.0 | 0.4 +/−0.9 | 0.8 +/−1.2 | 0.8 +/−1.2 | 1.7 +/−1.2 | 1.6 +/−1.2 | 0.58 |
| Sleeping | 0.5 +/−1.0 | 0.2 +/−0.8 | 0.8 +/−1.2 | 0.7 +/−1.2 | 1.5 +/−1.2 | 0.8 +/−1.2 | 0.06 |
OMWQ-HN: oral mucositis weekly questionnaire-head and neck cancer; OH: overall health; MTS: mouth and throat soreness.
a
Raw OH and MTS higher scores indicate better level of functioning or worse symptoms.
b
MTS: 0=no soreness 1=a little soreness 2= moderate soreness 3=quite a lot of soreness 4=extreme soreness.
c
Limitations due to MTS: 1=not at all 2=a little 3=quite a bit 4=very much