Table 2:
vmiRNA | Target | Function | Ref |
---|---|---|---|
miR-N367 | Nef | Block HIVNef expression in vitro (long term non-progressors) miR-N367 corresponding to suppression of Nef expression in vivo (Inhibition of Nef expression by siRNA/miR-N367 in mice) |
(92) |
miR-N367 | PABPC4 (iPABP) | MiR-N367 might repress the activation of lymphokine mRNA expression through targeting PABPC4 to help maintain viral latency. | (93) |
HIV-1-miR-H1 | AATF | Induced AATF gene knockdown within human mononuclear cells initiates their apoptosis. | (96) |
miR-H3 | HIV 5′ LTR | Interacts with the TATA box in HIV 5′ LTR miR-H3 upregulates HIV RNA transcription and protein expression. |
(94) |
vmiR99 | Stimulated human macrophage TNFα release | (109) | |
vmiR88 | Stimulated human macrophage TNFα release | (109) | |
vmiR-TAR | IER3, ERCC1, Caspase 8, Ikaros, Aiolos | Protects infected cells from apoptosis | (91, 109) |
vmiRNA#1–5 | - | Proteins involved in, for example, signal transduction, protein synthesis, and degradation, DNA methylation | (87) |
miR-TAR-3p | TAR (HIV) | Inhibitory effect on viral replication | (101) |