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. Author manuscript; available in PMC: 2021 Apr 1.
Published in final edited form as: HIV Med. 2019 Nov 22;21(4):246–278. doi: 10.1111/hiv.12822

Table 2:

HIV-encoded miRNAs

vmiRNA Target Function Ref
miR-N367 Nef Block HIVNef expression in vitro (long term non-progressors)
miR-N367 corresponding to suppression of Nef expression in vivo (Inhibition of Nef expression by siRNA/miR-N367 in mice)
(92)
miR-N367 PABPC4 (iPABP) MiR-N367 might repress the activation of lymphokine mRNA expression through targeting PABPC4 to help maintain viral latency. (93)
HIV-1-miR-H1 AATF Induced AATF gene knockdown within human mononuclear cells initiates their apoptosis. (96)
miR-H3 HIV 5′ LTR Interacts with the TATA box in HIV 5′ LTR
miR-H3 upregulates HIV RNA transcription and protein expression.
(94)
vmiR99  Stimulated human macrophage TNFα release (109)
vmiR88  Stimulated human macrophage TNFα release (109)
vmiR-TAR IER3, ERCC1, Caspase 8, Ikaros, Aiolos Protects infected cells from apoptosis (91, 109)
vmiRNA#1–5 - Proteins involved in, for example, signal transduction, protein synthesis, and degradation, DNA methylation (87)
miR-TAR-3p TAR (HIV) Inhibitory effect on viral replication (101)