Table 2.
Associations of CXCL13 with serological B-cell and inflammatory markers in primary Sjögren’s syndrome
| B-cell/inflammatory marker | Pearson correlation (r) | Benjamini–Hochberg adjusted p values |
|---|---|---|
| BAFF (pg/mL) | 0.263 | 0.0002 |
| B2M (mg/L) | 0.459 | < 0.0001 |
| CMBY (mg/L) | 0.375 | < 0.0001 |
| κ light chain (mg/L) | 0.358 | < 0.0001 |
| λ light chain (mg/L) | 0.338 | < 0.0001 |
| IgG (mg/mL) | 0.320 | < 0.0001 |
| κ–λ ratio | 0.135 | 0.0682 |
| IgA (mg/mL) | 0.110 | 0.0996 |
| IgM (mg/mL) | 0.084 | 0.2213 |
| C4 (g/L) | − 0.054 | 0.4484 |
| C3 (g/L) | − 0.065 | 0.3531 |
| Anti-Ro/SSA | – | < 0.0001 |
| Anti-La/SSB | – | 0.0003 |
| RF | – | 0.0039 |
| ESR (mm/1st h) | 0.300 | < 0.0001 |
| CRP (mg/L) | 0.061 | 0.3581 |
| WCC (× 109/L) | − 0.049 | 0.4447 |
Correlations of serological B-cell and inflammatory markers with CXCL13 concentrations measured for pSS patients without NHL at visit 1. The Pearson correlation coefficients (r) were calculated by the pairwise correlation method in JMP statistical software. p values lower than 0.05 were considered statistically significant. The false discovery rate (FDR) was controlled using the Benjamini–Hochberg (B–H) correction method
BAFF B-cell activating factor, B2M β2 microglobulin, CMBY combined free light chains, IgG immunoglobulin G, IgA immunoglobulin A, IgM immunoglobulin M, RF rheumatoid factor, ESR erythrocyte sedimentation rate, CRP C-reactive protein, WCC white blood cell count