Table 1.

Association of USP22 and SIRT1 expression and clinicopathological data of patients with hepatocellular carcinoma

Clinicopathological	Cases	USP22 expression, n			SIRT1 expression, n
		High	Low	Pα	High	Low	P
Paracancerous tissues	141	44	97	0.000	17	124	0.000
HCC	141	92	49		76	65
Age (years)
< 50	33	19	14	0.290	17	16	0.476
≥ 50	108	73	35		48	60
Sex
Man	124	78	46	0.114	55	69	0.262
Female	17	14	3		10	7
Tumor number
Single	135	87	48	0.342	60	75	0.062
Multifocality	6	5	1		5	1
Tumor differentiation
Well	5	2	3	0.467	0	5	0.000
Well/moderate, moderate	76	51	25		25	51
Poor	60	39	21		40	20
Tumor stage
I + II	94	59	33	0.177	44	50	0.811
III + IV	47	35	14		21	26
AFP (ng/ml)
< 400	8	6	2	0.324	3	5	0.121
≥400	53	30	23		35	18
Tumor size (5 cm)
< 5	24	17	7	0.528	8	16	0.168
≥ 5	117	75	42		57	60
MVI
Negative	105	62	43	0.008	46	59	0.352
Positive	36	30	6		19	17

α = 0.05, the two-tailed test level of significance

 P < 0.05 was considered a statistically significant difference