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. 2020 Mar 13;10:93. doi: 10.1038/s41398-020-0771-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Bars (mean) with error bars (standard error of the mean) illustrate total a and regional b–d alterations in the brain volume. a Deformation-based morphometry revealed a significantly smaller total brain volume in Df(h1q21)/+ mice compared with their controls, whereas Df(h15q13)/+ mice exhibited a significantly larger total brain volume. Regional volume changes between the three CNVs and their littermate controls illustrated in b–d demonstrate the percentage difference of the relative regional brain volumes (% of respective total brain volume) of the CNV compared with its WT control allowing to interpret the results as focal alterations independent from the whole-brain changes caused by the CNVs. Shadowed areas in b–d illustrate between-CNV differences (in relation to the respective WT) revealed by the ANOVA interaction effects (p < 0.05, Bonferroni-corrected for 104 brain regions and number of tests). % rel. vol. diff., percent relative regional volume difference; WT, wild type; del, deletion; *, significant at p < 0.05; **, significant at p < 0.01; ***, significant at p < 0.001; §, significant at p < 0.05 Bonferroni-corrected for 104 brain regions.