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. 2020 Mar 13;11:1383. doi: 10.1038/s41467-020-15031-3

Fig. 1. Schematic diagrams of the reagents used in this study.

Fig. 1

a Schematic diagram of ERK5 (full length) and ERK5 ΔTAD, which lacks the C-terminal extension. Functional domains with amino acid positions are: cytosolic targeting domain (1–77), kinase domain (48–383), activation-loop TEY motif (219–221), proline rich domain (PR) 1 (434–485) and 2 (578–701), nuclear localisation signal (NLS) (505–539), minimal transactivation domain (TAD) (664–789), and the N-terminal interaction domain (740-816). b Chemical structures of ERK5i: compounds 25, 26 and AX15836. c Schematic representation of the ERK5:MEF2D luciferase assay. d Chemical structure of the MEK5i, BIX02189. Structures were drawn using ChemDraw v16.0.