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. 2020 Mar 13;3:121. doi: 10.1038/s42003-020-0854-z

Fig. 4. Ultrastructural abnormalities of compact myelin in L-MPZ mice.

Fig. 4

Failed merging of major dense lines (MDL), increased periodicity of compact myelin, and outfoldings in 8-week-old L-MPZ homozygous (Hom) mice. a In the myelinated axon of a wild-type (WT) mouse, the MDL merged to form one thick dark line (MDL, blue lines in insertion) that was flanked by light intraperiod lines (IPL, space between red lines in insertion). Constant periodicity was observed (double headed arrows in insertion). b In a Hom mouse, the MDL failed to merge (blue separated lines in insertion) and periodicity increased (double-headed arrow in insertion). Myelin outfolding also formed (arrows). c–e In another myelinated fiber, MDL (e, light blue lines) did not merge (e, white arrowheads) and some larger spaces with patchy electron-dense materials were observed inside the unmerged major dense lines (e, black arrowheads). f Periodicity was larger in Hom. Bars, 500 nm (a–c) or 50 nm (d, e). ***p < 0.001 by Student’s t-test. Data are presented as mean ± SE of experiments. N = 15 axons (f).