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. 2020 Mar 13;11:1363. doi: 10.1038/s41467-020-15185-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Schematic diagram describing two nucleosome positioning-related variables (d_mean and d_var) relative to a given genomic position. b Classifying the genome into five equal portions by d_var and calculating the SNV densities. c, d Independent statistical significance of potential contributing factors to mutation rate variation, having controlled for other factors; b for SNVs and c INDELs. Tests for SNVs were performed separately at A/T and C/G sites (non-CpG and CpG contexts, respectively). Vertical red lines indicate the threshold for statistical significance (0.05). The p values were from the likelihood-ratio tests and were adjusted for multiple testing with Benjamini–Hochberg correction. us upstream; ds downstream. Source data are provided as a Source Data file.