Skip to main content
. 2020 Mar 13;11:1363. doi: 10.1038/s41467-020-15185-0

Fig. 3. De novo SNVs in strong nucleosomes display distinct mutation type frequencies and COSMIC mutational signatures.

Fig. 3

a Frequencies of 96 mutation types among de novo SNVs; six nucleotide substitutions in the context of the bases immediately 5′ and 3′ of the mutated site. SNVs are grouped into those overlapping strong nucleosomes and those elsewhere, and among the former into those overlapping with different classes of repeat elements. ↑ and ↓ indicate mutation types showing statistically significant differences relative to the genomic background SNV set (adjusted p < 0.05, two-sided Fisher’s exact test). b Percentage contribution of COSMIC mutational signatures among different groups of SNVs; only signatures with nonzero values are shown. Asterisks indicate mutational signatures displaying >1% increase relative to the genomic background SNV set. Brief summaries of the aetiologies of affected signatures are shown on the right (descriptions taken from the COSMIC website). Source data are provided as a Source Data file.