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. 2020 Mar 13;10:4701. doi: 10.1038/s41598-020-61473-6

Figure 5.

Figure 5

Severe NASH in LivKO mice fed the Western diet for 14 weeks starting at 6 weeks of age. (A) H&E staining of liver sections from male mice. (B) Levels of hepatic mRNAs for genes related to inflammation in male mice (n = 4–5). GAPDH was used as an internal invariant control. TNF-α, tumor necrosis factor-alpha; TGF-β, transforming growth factor-beta; IL-1β, interleukin-1β; MCP1, monocyte chemoattractant protein 1; TIMP1, tissue inhibitor of metalloproteinase 1. (C) Plasma levels of alanine transaminase (ALT) and aspartate transaminase (AST) in male mice (n = 5–6). *P < 0.05; **P < 0.01.