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. 2020 Mar 13;10:4703. doi: 10.1038/s41598-020-61586-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Cytotoxicity analysis of free DOX, CNT-DOX-Fe₃O₄, CNT-DOX-Fe₃O₄-Tf and CNT-DOX-Fe₃O₄-mAb nanobots incubated for 48 h with HCT116 cells. Cell viability study of treatments with free DOX and nanobots reveals a statistical improvement of CNT-DOX-Fe₃O₄-Tf and CNT-DOX-Fe₃O₄-mAb nanobots over free DOX treatment of HCT116 cells. The CNT-Fe₃O₄ nanobot does not show greater cytotoxic effect as compared to the control-CNT treatment. The free DOX shows limited toxicity to the model cancer cells at the end of the treatment. In contrast, the CNT-DOX-Fe₃O₄-Tf and CNT-DOX-Fe₃O₄-mAb nanobot loaded with an equivalent dose of DOX shows statistically significant improvement in the toxicity induced, suggesting greater efficacy of the DOX delivery by nanobot.