Table 5.
MAN-GF was applied to Colon neoplasms to predict the potential disease-related miRNAs, and 18 of top-20 predicted miRNAs have been confirmed according to recent experimental literatures.
| Num | miRNA | Disease | Evidence |
|---|---|---|---|
| 1 | hsa-mir-10a-5p | Colon neoplasms | dbDEMC 2.0 |
| 2 | hsa-let-7b-5p | Colon neoplasms | HMDD/ dbDEMC 2.0 |
| 3 | hsa-mir-183-5p | Colon neoplasms | dbDEMC 2.0 |
| 4 | hsa-mir-431-5p | Colon neoplasms | dbDEMC 2.0 |
| 5 | hsa-mir-136-5p | Colon neoplasms | dbDEMC 2.0 |
| 6 | hsa-mir-155-5p | Colon neoplasms | HMDD/ dbDEMC 2.0 |
| 7 | hsa-mir-324-5p | Colon neoplasms | dbDEMC 2.0 |
| 8 | hsa-mir-454-5p | Colon neoplasms | dbDEMC 2.0 |
| 9 | hsa-mir-29b-2-5p | Colon neoplasms | dbDEMC 2.0 |
| 10 | hsa-mir-205-5p | Colon neoplasms | HMDD/ dbDEMC 2.0 |
| 11 | hsa-mir-1-3p | Colon neoplasms | HMDD/ dbDEMC 2.0 |
| 12 | hsa-mir-218-5p | Colon neoplasms | dbDEMC 2.0 |
| 13 | hsa-mir-301a-5p | Colon neoplasms | dbDEMC 2.0 |
| 14 | hsa-mir-494-5p | Colon neoplasms | dbDEMC 2.0 |
| 15 | hsa-mir-376a-5p | Colon neoplasms | dbDEMC 2.0 |
| 16 | hsa-mir-149-5p | Colon neoplasms | dbDEMC 2.0 |
| 17 | hsa-mir-196a-1-3p | Colon neoplasms | unconfirmed |
| 18 | hsa-mir-4488 | Colon neoplasms | unconfirmed |
| 19 | hsa-mir-199a-5p | Colon neoplasms | dbDEMC 2.0 |
| 20 | hsa-mir-335-5p | Colon neoplasms | dbDEMC 2.0 |