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. 2020 Mar 13;10:4696. doi: 10.1038/s41598-020-61756-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Histological assessment of epithelial erosions in C57BL/6 mouse colon. (A) Characteristic H&E stains: left: ulceration of the epithelial layer, crypt damage, and infiltration of inflammatory cells into the colon mucosa in DSS treated animals; middle: reduction in epithelial damage for DSS + IL22Fc treated animals; right: naive animal. (B,C) Erosion length, extent of inflammation, and crypt loss analyses suggest DSS + IL22Fc treatment provides epithelial protection at near naive levels. For DSS, n = 10; for DSS + IL22Fc, n = 10; for naive, n = 5. All values presented are the mean ± S.D. One-way ANOVA was used to analyze variation; ***P < 0.0001.