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. 2020 Mar 13;10:4696. doi: 10.1038/s41598-020-61756-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Mucosal inflammation and gut permeability in CD40 colitis. (A) Elevated blood levels of orally dosed 800CW were observed in anti-CD40 treated animals. A reduction in permeability and blood levels was observed in anti-CD40 + anti-p40 treated animals and were similar to naive animals. For anti-CD40, n = 9; for anti-CD40 + anti-p40, n = 10; for naive, n = 5. (B) Visible signs of erosions for analysis were not observed in anti-CD40 treated animals. Rather, Iba-1 IHC was performed to quantify macrophage infiltration. Iba-1 IHC in brown; mucin staining in light blue. (C) Iba-1 image analysis suggests statistically significant higher staining in anti-CD40 animals vs anti-CD40 + anti-p40 animals. For anti-CD40, n = 10; for anti-CD40 + anti-p40, n = 8; for naive, n = 5. All values presented are the mean ± S.D. One-way ANOVA was used to analyze variation; ***P < 0.001.