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. 2020 Mar 13;10:4625. doi: 10.1038/s41598-020-61490-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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ApoE, Cyr61 and Dab2 overexpression recapitulate Tead overexpression phenotypic changes. (a) mRNA expression profiles of ApoE, Cyr61 and Dab2 in NSCs, BPs and NBNs. (b) Expression constructs used for overexpression. (c) Quantification of distribution of GFP⁺ transfected cells shows ApoE overexpression recapitulates Tead2 overexpression phenotype while Dab2 overexpression recapitulates the Tead1 overexpression phenotype. (d) Coronal sections of transfected cortices immunostained for GFP and Tbr1. (e) Quantification of Tbr1⁺GFP⁺ cells shows an increase upon overexpression of Cyr61 and Dab2, compared to GFP control in CP and all zones. Also see Figs. S7 and S8. Summaries of the quantifications are in Table S6. Scale bar = 50 μm. Data are shown as average ± SEM,*p = 0.05, **p = 0.01, ***p = 0.001, ****p = 0.0001.