Table 5.

miRNA-mRNA interactions identified in non-metastatic and metastatic colorectal patients by Pearson correlation analysis of the expression signal identified for EGFR transcripts, detected by the Affymetrix PrimeView human gene expression array and the microRNA 3.0 expression array.

miRNA	R2	p	Classification of interaction	Source of validation/prediction
Non-metastatic tumors
hsa-miR-134_st	−0.72	<0.001	Predicted	miRWalk, miRDB, MiRanda, DIANAmT
hsa-miR-3144-3p	−0.53	0.006	Predicted	miRWalk, miRDB, TargetScan
hsa-miR-4659a-5p	−0.52	0.007	Predicted	miRWalk, miRDB
hsa-miR-133b	−0.51	0.009	Predicted	miRDB
hsa-miR-651_st	−0.47	0.01	Predicted	miRDB, TargetScan
hsa-miR-27a-star_st	−0.46	0.02	Predicted	miRDB, MiRanda, TargetScan
hsa-miR-4476	−0.42	0.03	Predicted	miRDB, miRWalk,TargetScan
hsa-miR-155_st	−0.42	0.03	Predicted	miRDB, TargetScan
hsa-miR-1227_st	−0.42	0.03	Predicted	miRDB, miRWalk, TargetScan
hsa-miR-3126-3p	−0.42	0.03	Predicted	miRDB, TargetScan
Metastatic tumors
hsa-miR-4328	−0.71	0.001	Predicted	miRDB, TargetScan, MiRanda, DIANAmT
hsa-miR-651_st	−0.64	0.006	Predicted	miRDB, TargetScan, miRWalk
hsa-miR-3616-5p	−0.63	0.006	Predicted	miRDB, TargetScan
hsa-miR-876-3p	−0.62	0.008	Predicted	miRDB, miRWalk
hsa-miR-1233_st	−0.61	0.01	Predicted	miRDB, TargetScan, miRWalk
hsa-miR-548e_st	−0.60	0.01	Predicted	miRDB
hsa-mir-302c_st	−0.59	0.01	Predicted	miRDB
hsa-mir-373_st	−0.55	0.02	Predicted	miRDB, TargetScan, miRWalk
hsa-miR-3686	−0.55	0.02	Predicted	miRDB, TargetScan, miRWalk
hsa-miR-19a-star_st	−0.55	0.02	Predicted	miRDB, TargetScan, miRWalk
hsa-miR-646	−0.54	0.03	Predicted	miRDB, TargetScan, miRWalk
hsa-miR-4504	−0.53	0.03	Predicted	miRDB, TargetScan
hsa-mir-141_st	−0.52	0.03	Predicted	miRDB, TargetScan, miRWalk
hsa-miR-4659a-5p	−0.52	0.03	Predicted	miRDB, TargetScan

R²: Pearson correlation coefficient.