Figure 4.

Characterization of individual bile acid metabolism via individual models. (a) Overview of the mathematical model and parameters (as presented in (Sips et al., 2018), see also Appendix 1). (b) Identifiability and values of parameters responsible for synthesis and recycling of bile acids. Green markers represent well‐identified parameters, orange markers represent parameters that have a larger range, and red bars indicate unidentifiability. The dashed line indicates the parameter value found for population level bile acid dynamics in (Sips et al., 2018). (c) As (b), for parameters governing in conjugation and deconjugation. (d) As (b), for parameters determining the (postprandial) dynamics of the bile acid pool. (e) As (b), for parameters involved in composition