Figure 5.

Subject 4 is distinguished by insensitivity to colon transit speed. Ranked local sensitivity of the parameters for the individual models for a typical subject (I6) (left) and I4 (right). For all subjects, the three most sensitive parameters are the bile acid synthesis rate, the intestinal active uptake rate and the distal small intestinal transit speed (the order differs between subjects, data not shown). For all models apart from I4, the fourth most sensitive parameter is the colon transit speed, which is shown in black. For I4, however, the sensitivity of the colon transit speed is found to have less influence on the simulation, indicating that for this subject only, colon transit is not a determining factor. Note that the arrow denotes the location of the black bar (colon transit speed) for I4