Table 1.
The postprandial bile acid responses and its variability to three identical liquid mixed meal tests in eight healthy lean men
| Meal 1 | Meal 2 | Meal 3 | p‐value | CV% | Inter‐CV% | Intra‐CV% | |||
|---|---|---|---|---|---|---|---|---|---|
| Meal 1 | Meal 2 | Meal 3 | |||||||
| Total bile acids | |||||||||
| AUC | 927 [420] | 1,181 [616] | 1,142 [443] | NS | 5.8 | 53.1 | 35.0 | 22.6 | 20.5 [11.6 –29.4] |
| iAUC | 763 [368] | 999.5 [495.3] | 936 [295] | NS | 5.7 | 50.3 | 34.6 | 21.8 | 22.5 [15.0 – 29.9] |
| Primary bile acids | |||||||||
| AUC | 575 [128] | 678 [335] | 790 [327] | NS | 7.4 | 53.7 | 34.4 | 33.3 | 22.1 [12.9 – 31.3] |
| iAUC | 446 [166] | 487 [241] | 565 [329] | NS | 11.7 | 49.7 | 39.3 | 31.4 | 25.6 [17.2 – 34.0] |
| Secondary bile acids | |||||||||
| AUC | 383 ± 224 | 344 ± 172 | 341 ± 127 | NS | 5.6 | 58.50 | 49.8 | 37.3 | 21.1 [12.5 –29.7] |
| iAUC | 189 ± 126 | 206 ± 105 | 189 ± 93 | NS | 5.2 | 66.7 | 51.1 | 49.5 | 41.9 [23.6 – 60.2] |
| Glycine‐conjugated bile acids | |||||||||
| AUC | 633[338] | 686 [490] | 825 [473] | NS | 6.0 | 47.7 | 39.4 | 34.3 | 20.7 [12.4 – 29.1] |
| AUC | 489 [346] | 539 [454] | 585 [391] | NS | 8.2 | 43.7 | 43.0 | 37.4 | 23.6 [14.7 – 32.5] |
| Unconjugated bile acids | |||||||||
| AUC | 152 [165] | 154 [135] | 135 [213] | NS | 8.9 | 103.5 | 91.7 | 73.8 | 45.6 [18.0 – 73.2] |
| iAUC | 0.3 [100] | 8.6 [76.0] | 6.6 [96] | NS | 26.8 | X | X | X | X |
Data are presented as mean ± standard deviation when normally distributed or otherwise the median [interquartile range] is used. The inter‐ and intra‐CV are not displayed for the iAUC of the unconjugated bile acids since the iAUC was negative in our study.
Abbreviations: CV: coefficient of variance; iAUC: incremental area under the curve.