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. 2020 Mar 17;98(3):skaa057. doi: 10.1093/jas/skaa057

Table 4.

Change from baseline plasma long-chain fatty acids of adult female dogs fed different diets under restricted or ad libitum feeding regimens after spay surgery

Item Dietary treatment group1 P-values
COSH COSP HP-HF HP-HF-O SEM Treatment Time Treatment × Time
Week 12 Week 24 Week 12 Week 24 Week 12 Week 24 Week 12 Week 24
Change from baseline2: long-chain fatty acids, µg/mL
 Myristic acid, C14:0 −1.02bc −1.73bc −0.88bc −0.53bc −2.98cd −1.19b −0.09bc 2.40a 0.745 0.0159 0.0004 0.0005
 Palmitic acid, C16:0 −5.23a −49.24ab −30.95a −47.49a −203.70b −140.89ab −154.09ab −110.35ab 40.258 0.0127 0.3843 0.0295
 Stearic acid, C18:0 62.81 1.94 −6.8 17.94 −248.76 −123.97 −195.12 −117.69 40.626 0.0030 0.0769 0.0664
 Oleic acid, C18:1n9 −4.59 −38.31 −30.65 −29.31 −147.21 −96.28 −139.64 −112.73 43.664 0.1087 0.2116 0.0568
 Linoleic acid, C18:2n6 −2.86a −120.16ab 18.30a −110.94a −370.89b −294.83ab −341.24b −284.81ab 50.447 0.0006 0.1893 0.0014
 Gamma-linolenic acid, C18:3n6 −0.41 −0.88 −0.11 −0.10 −3.69 −1.40 −3.82 −3.08 0.774 0.0245 0.2103 0.2302
 Alpha-linolenic acid, C18:3n3 −0.41ab −1.60ab −0.63ab −1.52ab −2.87b −0.56a −2.68ab −1.25ab 0.834 0.8289 0.2396 0.0025
 Arachidonic acid, C20:4n6 131.06 49.52 9.59 77.43 −261.46 −75.14 −223.53 −127.53 58.425 0.0579 0.0629 0.1132
 Eicosapentaenoic acid, C20:5n3 −1.77 −0.69 −0.38 0.25 −0.55 1.17 14.59 24.68 1.731 <0.0001 0.0016 0.5290
 Docosahexaenoic acid, C22:6n3 0.81c −0.17c −2.92c −0.43c −6.54c −1.65c 27.20b 52.01a 4.449 <0.0001 <0.0001 <0.0001

1Dietary treatment group: COSH, sham-operated dogs fed a control diet containing a moderate amount of crude protein and dietary fiber; COSP, spayed dogs fed the control diet; HP-HF, spayed dogs fed a high-protein, high-fiber diet; HP-HF-O, spayed dogs fed a high-protein, high-fiber diet containing additional omega-3 and medium-chain fatty acids.

2Mean values during restricted feeding phase (change from week 0 to week 12) and ad libitum phase (change from week 0 to week 24).

a,b,c,dMean values within the same row with unlike superscript letters represent significant treatment × time interactions (P < 0.05).