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Differences in the AUC (ΔAUC) for (a) analgesia, (b) hypothermia, (c) catalepsy and (d) immobility after the XLR11treatment in four genotypes of mice. *P < .05, as compared to WT mice. (e–h) The effects of pretreatment with AM251, AM630, or CID16020046 on XLR11‐induced tetrad in WT mice (n = 6 per group). # P < .05, as compared to the baseline before the XLR11 injection in each group; *P < .05, as compared to “Veh + XLR” group
