Table 1.
Statistical analysis results (Treatment × Time interactions) from two‐way ANOVAs for repeated measures over time and drug dose
| Figure 1 | WT Δ9‐THC (s.c.) | CB1‐KO Δ9‐THC (s.c.) | CB2‐KO Δ9‐THC (s.c.) | GPR55‐KO Δ9‐THC (s.c.) |
|---|---|---|---|---|
| Analgesia | F 8,320 = 11.17; P < .05 | F 8,320 = 0.26; P > .05 | F 8,320 = 1.84; P > .05 | F 8,320 = 5.88; P < .05 |
| Hypothermia | F 8,324 = 7.25; P < .05 | F 8,324 = 0.96; P > .05 | F 8,324 = 8.11; P < .05 | F 8,324 = 34.07; P < .05 |
| Catalepsy | F 8,324 = 19.94; P < .05 | F 8,324 = 0.93; P > .05 | F 8,324 = 0.62; P > .05 | F 8,324 = 15.76; P < .05 |
| Immobility | F 24,320 = 5.57; P < .05 | F 8,320 = 1.54; P > .05 | F 8,320 = 4.5; P < .05 | F 8,320 = 2.31; P < .05 |
| Figure 3 | WT WIN55212‐2 (s.c.) | CB1‐KO WIN55212‐2 (s.c.) | CB2‐KO WIN55212‐2 (s.c.) | GPR55‐KO WIN55212‐2 (s.c.) |
|---|---|---|---|---|
| Analgesia | F 8,348 = 2.18; P < .05 | F 8,348 = 0.16; P > .05 | F 8,348 = 1.15; P > .05 | F 8,348 = 19.04; P < .05 |
| Hypothermia | F 8,360 = 18.35; P < .05 | F 8,360 = 0.43; P > .05 | F 8,360 = 11.19; P < .05 | F 8,360 = 33.55; P < .05 |
| Catalepsy | F 8,348 = 15.93; P < .05 | F 8,348 = 0.03; P > .05 | F 8,348 = 1.72; P > .05 | F 8,348 = 37.01; P < .05 |
| Immobility | F 8,340 = 11.79; P < .05 | F 8,340 = 0.83; P > .05 | F 8,340 = 1.48; P < .05 | F 8,340 = 29.39; P < .05 |
| Figure 5 | WT XLR‐11 (s.c.) | CB1‐KO XLR‐11 (s.c.) | CB2‐KO XLR‐11 (s.c.) | GPR55‐KO XLR‐11 (s.c.) |
|---|---|---|---|---|
| Analgesia | F 8,284 = 10.29; P < .05 | F 8,284 = 0.49; P > .05 | F 8,284 = 16.09 P < .05 | F 8,284 = 12.01; P < .05 |
| Hypothermia | F 8,288 = 17.13; P < .05 | F 8,288 = 0.55; P > .05 | F 8,288 = 19.90; P < .05 | F 8,288 = 26.15; P < .05 |
| Catalepsy | F 8,292 = 14.07; P < .05 | F 8,292 = 0.008; P > .05 | F 8,292 = 9.02; P < .05 | F 8,292 = 12.21; P < .05 |
| Immobility | F 8,268 = 14.98; P < .05 | F 8,268 = 1.34; P > .05 | F 8,268 = 15.94; P < .05 | F 8,268 = 9.43; P < .05 |
| Figure 7 | WT Δ9‐THC (i.c.v.) | CB1‐KO Δ9‐THC (i.c.v.) | CB2‐KO Δ9‐THC (i.c.v.) |
|---|---|---|---|
| Analgesia | F 8,292 = 9.44; P < .05 | F 8,292 = 1.79; P > .05 | F 8,292 = 0.89; P > .05 |
| Hypothermia | F 8,292 = 11.35; P < .05 | F 8,292 = 1.12; P > .05 | F 8,292 = 6.08; P < .05 |
| Catalepsy | F 8,236 = 12.78; P < .05 | F 8,236 = 1.16; P > .05 | F 8,236 = 2.14; P > .05 |
| Immobility | F 4,156 = 5.64; P < .05 | F 4,156 = 0.84; P > .05 | F 4,146 = 6.36; P < .05 |