Figure 2.

Effect of butyrate on physiological parameters and serum lipids in ApoE^−/− mice. ApoE^−/− mice were fed with HFD in the presence and absence of butyrate for 16 weeks. Average food intake (a) and body weight (b) per group through the entire 16‐week intervention period was measured. Serum total cholesterol (c), LDL‐cholesterol (d), non‐HDL‐cholesterol (e), HDL‐cholesterol (f), glucose (g), triglycerides (h), and total bile acid (i) were measured at 12 weeks, and average levels were calculated. Data are presented as mean ± SEM, n = 7–8 for chow and HFD groups, n = 9–10 for HFD + NaBu (200 and 400 mg·kg⁻¹) and atorvastatin groups (10 mg·kg⁻¹). * represent significance versus HFD